Cure for Cat Allergies?

If you are at all like me, this news is a breath of fresh air!  I’m tired of hearing friends, family and co-workers proclaim “I could never come to your house.  I would just die from cat allergies!”  To which I always respond, “Not to worry, you weren’t invited!”

On the flip side, I have come across many people who absolutely love cats and cat allergies have prevented them from adopting one of their own.  I’m thrilled that these people will soon have the opportunity to appreciate the great joy of cat companionship.

Now, I can only imagine, in a world without cat allergies – World Cat Domination is poised to happen sooner than we all expected!

cats get allergies gray cat smelling orange flower
Michael Harper for redOrbit.com – Your Universe Online

Good news for those allergic to cats: New research from the University of Cambridge has helped unlock some of the long-standing mysteries behind allergic reactions to cat dander. The British research team has discovered which biological toxin and receptors are responsible for triggering an extreme reaction to the combination of a cat’s skin flakes and saliva. It had been previously shown that a protein found in dander called Fel D 1 was seen as an invader of the immune system, but the new research identifies which part of the body reacts to this protein.

After conducting this research, the scientists now believe they can work towards delivering a drug to bring relief to those who experience reactions to dander from both cats and dogs. Researchers from the University of Nottingham had previously claimed they found a receptor in cells which kick stars an allergic reaction, though their findings are slightly different from those revealed this week by the University of Cambridge.

“We are hopeful that our research will lead to new and improved treatments for cat and possibly dog allergy sufferers,” said Dr. Clare Bryant, lead author of the research from the University of Cambridge’s Department of Veterinary Medicine, in a statement.

The Fel D 1 protein has often been hailed as the key component in cat dander that some react negatively to. The Cambridge researchers, however, have also found that a bacterial toxin called lipopolysaccharide (LPS) activates a receptor in the body known as the Toll-like receptor 4 (TLR4).

This receptor is also responsible for other allergic reactions, such as those from dust mites and metals.

To understand exactly how Fel D 1 and LPS react to TLR4 the team exposed human cells to these elements and observed the reactions. When LPS was present, the cells quickly began to trigger an allergic reaction, inflaming the skin when in the presence of Fel D 1.

Next the team used a drug that has been shown to block TLR4, thereby reducing its ability to react negatively when in the presence of normally allergy-inducing compounds. When the cells were exposed to Fel D 1 and LPS after being treated with the medication, there was no inflammatory response.

Dr. Bryant explains their conclusion this way:

“How cat dander causes such a severe allergic reaction in some people has long been a mystery. Not only did we find out that LPS exacerbates the immune response’s reaction to cat dander, we identified the part of immune system that recognizes it, the receptor TLR4.”

Taking their research one step further, the team employed the same TLR4 blocking technique in the presence of Can f 6, the protein found in dog dander that also induces an allergic response. The results from both tests were the same with the TLR4-inhibiting drug blocking a negative response when in the presence of dander.

In 2011, researchers from the University of Nottingham also claimed they had unlocked the mysteries of allergic reactions to dander. Their study pinpointed the source of a reaction to the mannose receptor (MR), a receptor found on the surface of dendritic cells. These cells are often the first to encounter allergens such as dander and the team deduced they could be responsible for triggering a response. They also found that MR is necessary for the body to react negatively to Fel D 1 as a foreign invader of the immune system and thereby start reacting negatively to it as a precaution.

Source: Michael Harper for redOrbit.com – Your Universe Online

You might also enjoy these articles…

Cute British Shorthair cat in litter box at home

Litter Mixology: Creating the Perfect Blend for Your Cat’s Litter Box

As a devoted cat parent, I'm always on the lookout for ways to make my feline friends happier and our home cleaner. No one wants guests to instantly know they have a cat the moment they step into their home, particularly if the cat is nowhere in sight. One of the...
Ginger striped kitten sits on the wheel of a car under the mudguard. Portrait of a cat with selective focus. Dangerous situation.

Lucky Cat Escapes Close Call With Two Pit Bulls

Source: NY Post In a shocking event that vividly illustrates the unpredictable nature of animal behavior, a quiet neighborhood in Florida became the backdrop for a dramatic confrontation. Two determined dogs, in their relentless pursuit of a cat, caused a staggering...
Closeup Portrait of Devon-Rex Looking in Camera on Gray

Devon Rex: Personality, Origin and Health Conditions

The Devon Rex, a feline marvel that’s all set to sprinkle some fairy dust into your life! With ears that could rival a bat’s radar and curls to make even the most seasoned hairstylist envious, these charming critters are nothing short of a living, purring fantasy novel.

RSVP Photo Banner for Cancer Care Paw event

A Paws for Wellness: The CancerCare PAW Program and the Support It Offers to Those Fighting Cancer

In the grueling fight against cancer, patients often seek comfort in the steadfast company of their pets. The joyous wag of a dog’s tail or the gentle nuzzle of a cat can speak volumes in silent, understanding support. This unbreakable bond has not gone unnoticed by CancerCare, which has embarked on helping patients who are also the proud caregivers to their beloved animal companions. The Pet Assistance and Wellness Program (PAW) by CancerCare honors the role pets play in the lives of the patients by providing a much-needed support cushion during their treatment.

lonely young girl holding a cat who is offering emotional support to the girl.

How Cats Alleviate Loneliness

The global pandemic has brought loneliness into sharp focus, shedding light on a long-standing struggle for many. Lockdowns and social distancing have unveiled the emotional toll, underscoring the importance of companionship. In these isolated times, pets, particularly cats, have emerged as silent champions, providing much-needed solace and companionship.

Cat DIY Hammock

DIY Cat Hammock

Looking for a fun, feline-centric project for the weekend? Try this DIY Hammock! Crafting a cozy haven for your feline friend doesn't have to be complicated or expensive. In fact, with a little creativity and some basic supplies, you can create a stylish and...